Orateur
Description
Souad DEKAR1, 2, *, Merzougui Moufida1,3 sabrina bendia1,4 and Kamel OUARI1
1Laboratory of Electrochemistry, Molecular Engineering and Redox Catalysis, Faculty of Technology, Ferhat Abbas University, Setif 19000, Algeria.
2Department of Chemistry, Faculty of Sciences, Ferhat Abbas University, Setif 19000, Algeria.
3 Département Génie de l’Environnement, Faculté des Sciences et de la Technologie, Université Mohamed El-Bachir El-Ibrahimi, 34030 Bordj Bou-Arreridj, Algeria.
4Laboratory of Agro-Food Engineering (GENIAAL), Institute of Nutrition, Food, and Agro-Food Technologies (INATAA), Frères Mentouri University – Constantine 1
A new Fe(II) complex, FeClL, was synthesized by reacting FeCl₃ with a tetradentate OONN Schiff base ligand, 1,2-bis((E)-5-hydroxy-2-hydroxybenzylideneamino)benzene, in methanol at reflux (65 °C). Its structure was confirmed using UV–Vis and IR spectroscopy, melting point analysis, elemental analysis (CHN), and mass spectrometry. The compound showed antioxidant activity in the DPPH assay with an IC₅₀ of 33.16 μg/mL, comparable to BHT (38.40 μg/mL), and exhibited antibacterial effects against Pseudomonas aeruginosa and Bacillus subtilis. DFT calculations were used to optimize molecular structure and determine electronic, vibrational, and quantum chemical properties, with theoretical results aligning well with experimental data. Molecular docking suggested potential inhibitory interaction with Alzheimer’s disease-related targets.
