Orateur
Description
The advancements in modern therapeutics are a direct result of numerous research efforts, which have been developed in the fields of synthesis, analysis, and control of pharmaceutical products.
In recent years, it has been demonstrated that organic compounds containing azomethine groups are important compounds in chemistry, biochemistry, and coordination chemistry due to their flexibility, ease of preparation, exceptional chelating ability, and broad spectrum of biological and pharmaceutical activities, such as antimicrobial, anti-inflammatory, and anticancer properties. Consequently, the chemistry of Schiff bases has always been a promising area of research.
In this context, we are interested in synthesizing new symmetric and asymmetric azines through the reaction of hydrazine with carbonyl derivatives, and the characterization of the obtained products will be carried out using IR and UV-Vis spectroscopic methods, as well as proton and carbon NMR and single-crystal X-ray diffraction (XRD) at 100 K. Furthermore, a biological evaluation will be performed to assess the potential application of our synthesized compounds in the pharmaceutical field. In this study, we conducted an antifungal test against the FOL fungus, and the results showed that our products exhibited remarkable inhibitory activity. Additionally, isovanillin azine was evaluated in silico for its inhibitory activity against the HTLV-1 protease (2B7F) and showed potential as an anticancer drug.
