Orateur
Description
In theory, several methods are available to measure the antioxidant activity of foods and bioactive molecules, these techniques are called following the name of the substance used as a source of free radicals.
In our study, the in vitro antioxidant activity of a new coumarin derivative named MSMet was demonstrated by chemical technique namely: DPPH free radical scavenging, in comparison with the ascorbic acid standard. Pharmacokinetic studies of Mob aniline were analyzed to show Lipinski's rules via in-silico methods of Swiss-ADME. The drug likeness calculations were carried out in Molinspiration analyses. From the results obtained, it can be deduced that the compound studied, MSMet, is a powerful scavenger of DPPH- radicals, possessing an antioxidant power close to that of ascorbic acid, with an IC50 value of 70.76 µg.ml-1. In agreement with the present results, previous work has shown that electron-withdrawing groups (-OH, -CH3 and -Cl) substituted on the benzopyrone ring significantly increase the antioxidant activity of any molecule. The compound complies with Lipinski's rule, which implies good oral bioavailability.
