29 avril 2025
Setif1- University Ferhat ABBAS
Fuseau horaire Africa/Algiers

3D-QSAR STUDY ON ANTIOXIDANT ACTIVITY OF CAFFEIC ACID DERIVATIVES

Non programmé
20m
Faculté des sciences (Setif1- University Ferhat ABBAS)

Faculté des sciences

Setif1- University Ferhat ABBAS

Campus El Bez, Algiers Road, Setif 19137, Algeria
Study of natural substances and their pharmaceutical applications.

Orateur

Dr Abderahmane Belafriekh (Laboratory of LCPMM, Faculty of sciences, University of Blida1, P.O. Box 270 Blida, 09000, Algeria.)

Description

Caffeic acid (CA) derivatives are a class of natural compounds found in various sources; these compounds have been shown a huge range of biological activities, such as antioxidant, anti-inflammatory, and anti-diabetic properties. In this study, CA derivatives were collected from literature with antioxidant activity values to generate a 3D-QSAR model. The model was generated successfully with a high regression coefficient R²= 0.96 and a good cross-validated determination coefficient Q2cv= 0.53 for the training set. Furthermore, the model generated showed good predictive ability, with a high predictive value Q2= 0.76 for the test set. The generated 3D contour cubes were applied to find the structural properties important for the antioxidant activity.

Authors

Dr Abderahmane Belafriekh (Laboratory of LCPMM, Faculty of sciences, University of Blida1, P.O. Box 270 Blida, 09000, Algeria.) Aicha Laoud (Universite constantine3)

Documents de présentation

Aucun document.