Caffeic acid (CA) derivatives are a class of natural compounds found in various sources; these compounds have been shown a huge range of biological activities, such as antioxidant, anti-inflammatory, and anti-diabetic properties. In this study, CA derivatives were collected from literature with antioxidant activity values to generate a 3D-QSAR model. The model was generated successfully with a...
1- Synthèse
2- Test de piégeage du radical anion superoxyde par voie électrochimique
3- Conclusion
The advancements in modern therapeutics are a direct result of numerous research efforts, which have been developed in the fields of synthesis, analysis, and control of pharmaceutical products.
In recent years, it has been demonstrated that organic compounds containing azomethine groups are important compounds in chemistry, biochemistry, and coordination chemistry due to their flexibility,...
Abstract – The genus Atriplex, part of the Amaranthaceae family, comprises a diverse array of species predominantly inhabiting arid, semi-arid, and saline ecosystems. These plants have garnered significant attention for their bioactive potential, particularly in the context of antioxidant properties. This study investigates the antioxidant efficacy of extracts derived from an Atriplex species,...
Abstract – Poly(vinyl chloride) (PVC)-Maghnite nanocomposites were prepared by melt blending using a two-roll mixer. This study aims to evaluate the effect of incorporating a natural Algerian clay, Maghnite, extracted from the Roussel deposit in Maghnia (northwest Algeria), on the properties of PVC. This nanofiller was incorporated at low contents (1 to 4 phr) in two forms: raw (RMMT) and...
Abstract
Naproxen (NAP) is a non-steroidal anti-inflammatory drug (NSAID) of the arylacetic acid group, Naproxen is used to relieve the pain, inflammation and stiffness. Enantiomeric purity of naproxen is important, as the R- isomer is hepatotoxic while the S- isomer is safe. Also, the S- isomer of the drug has 28 times than the anti-inflammatory activity of the R- isomer. The use of an...
This research examines the synthesis of three Schiff bases, accomplished by the condensation reaction of dehydroacetic acid (DHA) with primary amines. The resultant compounds were evaluated using several analytical methods, including UV-visible spectroscopy, Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and melting point determination.
Additionally, the...
Dans ce travail nous nous sommes intéressés au développement de nouveaux inhibiteurs potentiels de nt-MGAM afin d’enrichir les classes thérapeutiques des médicaments anti diabète type2. La première étape a constitué en une étude de docking moléculaire, dans le site actif de l’enzyme nt-MGAM, sur un ensemble de dérivées du salacinol afin de déterminer les caractéristiques communes responsables...
Peganum harmala L. (Harmel) is a plant traditionally utilized in Algerian medicine for the treatment of various ailments. This study investigates the immunomodulatory effects of two extracts derived from P. harmala seeds: the crude seed extract (CSE) and the total alkaloid extract (TAE). Female NMRI white mice (Mus musculus) were administered CSE (20.72 mg/kg) and TAE (37.75 mg/kg) via...
Abstract
Essential oils have important biological activities. Which leads to the study of the biological activity of these essential oils. The aim of this work is to study the antibacterial, antifungal and antioxidant capacities of extracts of cumin and fennel, and to compare the two compounds. The extraction was carried out by hydrodistillation of the clevenger type,...
The therapeutic potential of plants from the Lamiaceae family, particularly Mecromeria species, has attracted significant attention in recent years due to their diverse medicinal properties with notable efficacy in addressing a spectrum of health issues, including Alzheimer's disease, cardiovascular disorders, and cancer [1, 2, 3].
Our research aims to evaluate the antioxidant potential of...
Abstract
Recognizing the significant body of research on azomethines and their substantial contribution to the scientific literature is essential. These compounds have attracted considerable attention over an extended period and have been widely employed in medicine for the treatment of various disorders. Owing to their remarkable ability to form complexes with metal ions, azomethines are...
Souad DEKAR1, 2, *, Merzougui Moufida1,3 sabrina bendia1,4 and Kamel OUARI1
1Laboratory of Electrochemistry, Molecular Engineering and Redox Catalysis, Faculty of Technology, Ferhat Abbas University, Setif 19000, Algeria.
2Department of Chemistry, Faculty of Sciences, Ferhat Abbas University, Setif 19000, Algeria.
3 Département Génie de l’Environnement, Faculté des Sciences et de la...
L’impact des liaisons hydrogène sur les propriétés optiques des hydrazones de pyridine n’avait jusqu’ici pas été considéré comme déterminant. Cependant, cette étude révèle que le contrôle de ces photo-commutateurs dépend étroitement de la force des liaisons hydrogène. Nous examinons ici 18 molécules photo-commutables d’hydrazones de pyridine (isomères E/Z) pour évaluer l’influence des liaisons...
L’EXTRACTION ASSISTEE PAR MICRO-ONDES DE PRODUITS NATURELS D’ORIGINE VEGETALE
Rouari Razika¹, Kaarar Mohamed Nadjib¹,2
¹ Laboratoire de chimie analytique, département de pharmacie, faculté de médecine Sétif
2Laboratoire Biopharmacie et Pharmacotechnie, Faculté de médecine, Sétif
Résumé :
L'extraction assistée par micro-ondes (EAM) est une méthode innovante et efficace pour extraire des...
In theory, several methods are available to measure the antioxidant activity of foods and bioactive molecules, these techniques are called following the name of the substance used as a source of free radicals.
In our study, the in vitro antioxidant activity of a new coumarin derivative named MSMet was demonstrated by chemical technique namely: DPPH free radical scavenging, in comparison with...
Alzheimer’s disease (AD) is related to increasing age. It is mainly characterized by progressive neurodegenerative disease, which damages memory and cognitive function. The cholinergic hypothesis is a key theory used to explain the development of Alzheimer's disease (AD). It suggests that AD results from a decline in the neurotransmitter acetylcholine (ACh). Many AD treatments are based on...
ABSTRACT
Nowadays much attention has been given to hybrid organic–inorganic materials crystals because of their large hyperpolarizabilities and high laser damage resistance compared to inorganic materials. These hybrid materials owing their interesting chemical and physical properties and innovative applications. In this context and devices with innovative properties, we have synthesized a...
Introduction
La chimie organique constitue la base de la découverte et du développement de nombreux médicaments qui doivent répondre à des critères stricts de sécurité, d’efficacité et d’innocuité, nécessitant un contrôle qualité rigoureux avant toute mise sur le marché.
Cette étude vise à montrer l’application de la chimie dans les domaines médicinal et industriel en vérifiant la...
Schiff bases are the most widely used organic compounds. They have been shown to exhibit a broad range of biological activities, including antifungal, antibacterial, antimalarial, antiproliferative, anti-inflammatory, antiviral, and antipyretic properties. This work aimed to synthesis the Schiff base. Schiff bases are studied widely due to their synthetic flexibility, selectivity and...
Abstract :
Evaluation of the antibacterial activity of our samples α-Fe2O3@Fe3O4 (CS), GO, GO/ α-Fe2O3@Fe3O4 (Hyb.). was carried out using the well diffusion method based on the protocol described by Thana et al [1] with a slight modification. 15ml Muller-Hinton agar was poured into Petri dishes and allowed to solidify. Bacterial cultures were spread evenly over the agar surface and 8mm...
